Heat acclimation induces basal N-cadherin and post injury detachment of the cadherin-catenin complex.

<p>Representative western blots of N cadherin, showing significant basal induction of N cadherin which lasts up to 6(HA) as compared with normothermic mice (NT) (<i>A</i>). β-catenin was immunoprecipitated (IP) with protein A beads and separated on SDS-PAGE gels. Immunoblotting (IB) of N cadherin indicates disassociation of cadherin-catenin complex in injured HA mice. (−) Immunoprecipitation of non β-catenin related protein (Bcl-xL) with the same beads. (+) input from non immunoprecipitation blot of 60 µg protein from injured HA brain (<b><i>B</i></b>). Values represent the mean ± SEM. n = 5–6 per group. *<i>p</i><0.05 vs. NT mice, **<i>p</i><0.05 vs. sham mice, within the same group.