Quantification of NF-κB p65 staining in pulmonary vascular cells.
- Laura C. Price (467011)
- Gaetano Caramori (338672)
- Frederic Perros (467012)
- Chao Meng (467013)
- Natalia Gambaryan (467014)
- Peter Dorfmuller (467015)
- David Montani (467016)
- Paolo Casolari (347143)
- Jie Zhu (126574)
- Konstantinos Dimopoulos (467017)
- Dongmin Shao (186047)
- Barbara Girerd (467018)
- Sharon Mumby (467019)
- Alastair Proudfoot (467020)
- Mark Griffiths (467021)
- Alberto Papi (347149)
- Marc Humbert (23466)
- Ian M. Adcock (133335)
- S. John Wort (467022)
Publication date
October 2013
DOIAbstract
<p>(A) Overall p65+ was increased in pulmonary arterial endothelial cells (EC) (62.3±2.9 vs. 14.4±3.8%, ***p<0.001), pulmonary arterial smooth muscle cells (PASMC) (22.6±2.3 vs. 11.2±2.0%, ***p<0.001) in PAH versus controls and (B) within pulmonary <i>arterioles</i> in both EC (86.4±3.28 vs. 4.68±2.29%, p<0.0001) and PASMC (39.2±5.29 vs. 6.39±2.61%, ***p<0.001). (C) In pulmonary endothelial cells, percentage p65+ was increased in pulmonary arterial EC in PAH versus control subjects following subdivision into cytoplasmic p65+ (23.7±1.6 vs. 8.0±2.2%, PAH, ***p<0.001) and nuclear p65+ (38.5±2.1 vs. 6.4±1.6%, ***p<0.001). Results represent mean ± SEM of 12 PAH and 14 control samples.</p
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