Effect of XO inhibitor allopurinol (ALLO) on IH-induced autonomic dysfunction.

<p>Adult rats were exposed to 10 days of IH and were treated daily with either vehicle (IH) or ALLO (65 mg/Kg/day; oral gavage; IH+ALLO). Control experiments were performed on rats exposed to normoxia (N). <b>A–B</b> Increases in mean arterial blood pressure and plasma norepinephrine levels. <b>C</b>. Decreased aconitase activity (index of ROS generation) levels, <b>D</b> Increased XO activity and <b>E.</b> HIF-2α degradation in adrenal medullae. Data presented in A–E are mean ± S.E.M. from 8 rats in each group. *p<0.05. n.s. not significant p>0.05.