<p>The regions indicated by the orange bars in the left panel were subjected to the plasmid-stability assay in COLO 320DM cells, as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0077350#pone-0077350-g002" target="_blank">Figure 2</a>. The results are shown in the right panel. The data suggest that the gray rectangular region drawn in the left panel has HSR-generation activity.</p
Gene amplification in human cancer cells generates 2 cytogenetically identifiable structures: extrac...
Gene amplification in human cancer cells generates 2 cytogenetically identifiable structures: extrac...
<p>(<b>A</b>) Plasmids containing (CTG)<sub>35</sub> repeats (12 µg) were transfected into HEK293-H ...
<p><b>(3)</b>. The G5 fragment, which exhibited the highest HSR-generation activity in <a href="http...
<p><b>(1)</b>. The ß-globin locus and the positions of two reported replicators, Rep-P and Rep-I [<a...
<p>A. To examine the effect of the AR1 MAR sequence of the vector plasmid, we removed it and constru...
<p>The IR/MAR (+) plasmid generated double minutes (DMs) (A) or homogeneously staining regions (HSRs...
Gene amplification plays a pivotal role in malignant transformation of human cells. A plasmid with b...
<p>Immunofluorescence was performed by cotransfecting Hela cells with a plasmid coding for Vpr-GFP (...
<p>A. Two transgenes containing sequences from the human beta-globin Locus Control Region (HS432), t...
<div><p>Plasmids with both a mammalian replication initiation region (IR) and a matrix attachment re...
Plasmids with both a mammalian replication initiation region (IR) and a matrix attachment region (MA...
<p>(A) NHEJ was monitored using the pEJ5-GFP plasmid integrated at interstitial (not shown) or telom...
<p>Representative images obtained in this study are shown. Plasmid pTV-Rep-P bearing full-length Rep...
<p><b>A)</b> Genetic composition of theHPRT-dup-GFP system, <b>B-D</b>) Frozen sections of liver, <b...
Gene amplification in human cancer cells generates 2 cytogenetically identifiable structures: extrac...
Gene amplification in human cancer cells generates 2 cytogenetically identifiable structures: extrac...
<p>(<b>A</b>) Plasmids containing (CTG)<sub>35</sub> repeats (12 µg) were transfected into HEK293-H ...
<p><b>(3)</b>. The G5 fragment, which exhibited the highest HSR-generation activity in <a href="http...
<p><b>(1)</b>. The ß-globin locus and the positions of two reported replicators, Rep-P and Rep-I [<a...
<p>A. To examine the effect of the AR1 MAR sequence of the vector plasmid, we removed it and constru...
<p>The IR/MAR (+) plasmid generated double minutes (DMs) (A) or homogeneously staining regions (HSRs...
Gene amplification plays a pivotal role in malignant transformation of human cells. A plasmid with b...
<p>Immunofluorescence was performed by cotransfecting Hela cells with a plasmid coding for Vpr-GFP (...
<p>A. Two transgenes containing sequences from the human beta-globin Locus Control Region (HS432), t...
<div><p>Plasmids with both a mammalian replication initiation region (IR) and a matrix attachment re...
Plasmids with both a mammalian replication initiation region (IR) and a matrix attachment region (MA...
<p>(A) NHEJ was monitored using the pEJ5-GFP plasmid integrated at interstitial (not shown) or telom...
<p>Representative images obtained in this study are shown. Plasmid pTV-Rep-P bearing full-length Rep...
<p><b>A)</b> Genetic composition of theHPRT-dup-GFP system, <b>B-D</b>) Frozen sections of liver, <b...
Gene amplification in human cancer cells generates 2 cytogenetically identifiable structures: extrac...
Gene amplification in human cancer cells generates 2 cytogenetically identifiable structures: extrac...
<p>(<b>A</b>) Plasmids containing (CTG)<sub>35</sub> repeats (12 µg) were transfected into HEK293-H ...