Genetic association study of CYP1A1 polymorphisms identifies risk haplotypes in nonsmall cell lung cancer
- Wright, C. M.
- Larsen, J. E.
- Colosimo, M. L.
- Barr, J. J.
- Chen, L.
- McLachlan, R. E.
- Yang, I. A.
- Bowman, R. V.
- Fong, K. M.
Publication date
January 2010
DOI Publisher
European Respiratory Society (ERS)Abstract
Lung cancer remains a leading cause of disease globally, with smoking being the largest single cause. Phase I enzymes, including cytochrome P(450), family 1, subfamily A polypeptide 1 (CYP1A1), are involved in the activation of carcinogens, such as polycyclic aromatic hydrocarbons, to reactive intermediates that are capable of binding covalently to DNA to form DNA adducts, potentially initiating the carcinogenic process. The aim of the present study was to investigate the association of CYP1A1 gene polymorphisms and haplotypes with lung cancer risk
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