ADAM12-Lb is localized to the endoplasmic reticulum.

<p>MCF10A cells stably expressing ADAM12-La or ADAM12-Lb were fixed, permeabilized, and stained with anti- ADAM12 antibody (A, D, G, J, M, P), anti-KDEL antibody (an endoplasmic reticulum marker; B, E), anti-TGN38 antibody (a trans-Golgi marker; H, K), anti-EEA1 antibody (an early endosomal marker; N, Q), and DAPI. Overlay images are shown in panels C, F, I, L, O, R. Partial co-localization of ADAM12-La and EEA1 is indicated by white arrows. Bar, 20 µm.