Comparisons of the predicted 3D structure of the <i>Sp</i>Tube death domain (DD).

<p>(14 aa to 144 aa, yellow) and the crystal structure of DmTube DD (PDB ID: 1d2z, chain B) (red) (A); the predicted 3D structure of <i>Sp</i>Pelle DD (13 aa to 109 aa, yellow) and the solution structure of DmPelle DD (PDB ID: 1d2z, chain A) (red) (B); the predicted 3D structure of <i>Sp</i>Tube kinase domain (251 aa to 488 aa, yellow) and the crystal structure of human IRAK4 kinase domain (PDB ID: 2nru, chain B) (red) (C); and the predicted 3D structure of <i>Sp</i>Pelle kinase domain (540 aa to 825 aa, yellow) and the crystal structure of human IRAK4 kinase domain (PDB ID: 2nru, chain B) (red) (D). Residues required for binding to MyD88 (blue) and Pelle (red) are indicated (A). The position of R (ARG) residue in RD dipeptide, which is the hallmark of Tube-like kinases, is also shown (C). These four predicted structures merge well with their corresponding templates.