Dynamic contrast enhancement of the LV myocardium apical (orange) and inferolateral (blue) in Patient 2 with a HR varying from 60–110 bpm and several extrasytoles during CT perfusion examination.

<p>Perfusion analysis of original images shows irregular zigzag pattern of the resulting curves (a). A continuous run of the time density curves is illustrated after motion correction and spatio-temporal filtering (b). Both curves (orange and blue) illustrate normal contrast enhancement of the LV myocardium with no evidence of perfusion deficit. Figs. c-f: Shown are the axial images (and the ROIs) at two different instances in time – the original uncorrected (c, d) and after motion correction plus spatio-temporal smoothing (e, f). Images c and e are from cardiac cycle 3; d and f are from cardiac cycle 8. In the original images (c & d), the two ROIs do not cover the same area of the myocardium at both time points, but instead cover adjacent tissue and the contrast-filled lumen of the LV, resulting in several spikes in (a). In contrast, consistent measurements of the same part of the myocardium after motion correction (e & f) leading to coherent time-density curves (b) for both ROIs. All CT images are presented using the same window level and window width.