Effects of GDC0941 and AZD6244 on BxPC-3 xenograft model.
- Hua Zhong (1421908)
- Cesar Sanchez (372265)
- Dirk Spitrzer (468722)
- Stacy Plambeck-Suess (468723)
- Jesse Gibbs (468724)
- Williams G. Hawkins (468725)
- David Denardo (468726)
- Feng Gao (3548)
- Robert A. Pufahl (468727)
- Albert C. Lockhart (468728)
- Mai Xu (344558)
- David Linehan (468729)
- Jason Weber (468730)
- Andrea Wang-Gillam (468731)
Publication date
October 2013
DOIAbstract
<p>A: 1×10<sup>6</sup> BxPC-3 pancreatic cancer cells were injected s.c. into the right flank of female nude mice. Mice received vehicle (0.5% methylcellulose /0.2% Tween-20), 50 mg/kg GDC0941 QD, 25 mg/kg AZD6244 BID, or 50 mg/kg GDC0941 QD plus 25 mg/kg AZD6244 BID orally for 18 days. Data are presented as mean ± SE. *p values were determined by unpaired t-test. B: Kaplan-Meier survival curves of xenografts receiving vehicle, GDC0941 alone, AZD6244 alone and GDC0941-AZD6244 in combination.</p
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