Synergistic effects of GDC0941-AZD6244 combination therapy on cell viability and proliferation.
- Hua Zhong (1421908)
- Cesar Sanchez (372265)
- Dirk Spitrzer (468722)
- Stacy Plambeck-Suess (468723)
- Jesse Gibbs (468724)
- Williams G. Hawkins (468725)
- David Denardo (468726)
- Feng Gao (3548)
- Robert A. Pufahl (468727)
- Albert C. Lockhart (468728)
- Mai Xu (344558)
- David Linehan (468729)
- Jason Weber (468730)
- Andrea Wang-Gillam (468731)
Publication date
October 2013
DOIAbstract
<p>BxPC-3 (A) and MIA PaCa-2 cells (B) were treated with GDC0941 alone, AZD6244 alone or GDC0941-AZD6244 in combination. Results were analyzed according to the Chou-Talalay method [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0077243#B18" target="_blank">18</a>]. The combination index (CI) values were calculated by using CalcuSyn software. PANC-1 (C) and Capan-2 cell line (D) were treated with GDC0941 at 400 nM, AZD6244 at 200 nM or combination. * p value <0.05 compared with control or single agent alone.</p
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