<div><p>Hepatocarcinogenesis is a multistep process that starts from fatty liver and transitions to fibrosis and, finally, into cancer. Many etiological factors, including hepatitis B virus X antigen (HBx) and p53 mutations, have been implicated in hepatocarcinogenesis. However, potential synergistic effects between these two factors and the underlying mechanisms by which they promote hepatocarcinogenesis are still unclear. In this report, we show that the synergistic action of HBx and p53 mutation triggers progressive hepatocellular carcinoma (HCC) formation via src activation in zebrafish. Liver-specific expression of HBx in wild-type zebrafish caused steatosis, fibrosis and glycogen accumulation. However, the induction of tumorigenesis b...
<p>Immunohistochemical analyses of phosphorylated erk1/2 (p-erk), phosphorylated akt (p-akt), myc, v...
<p>(<b>A-C</b>) Control 4-month-old zebrafish showing the liver (L, outlined) positioned in the body...
Liver is the largest organ in the human body, and it regulates many physi-ological processes. Many s...
Hepatocarcinogenesis is a multistep process that starts from fatty liver and transitions to fibrosis...
[[abstract]]Hepatocarcinogenesis is a multistep process that starts from fatty liver and transitions...
Hepatocarcinogenesis is a multistep process that starts from fatty liver and transitions to fibrosis...
[[abstract]]The primary type of liver cancer, hepatocellular carcinoma (HCC), has been associated wi...
[[abstract]]Aflatoxin B1 (AFB1) and the hepatitis B virus X antigen (HBx) are linked to the formatio...
[[abstract]]Liver is the largest organ in the human body, and it regulates many physiological proces...
SUMMARY Human liver cancer is one of the deadliest cancers worldwide, with hepatocellular carcinoma ...
<div><p>Hepatocellular carcinoma (HCC) is currently one of the top lethal cancers with an increasing...
Hepatocellular carcinoma (HCC) is currently one of the top lethal cancers with an increasing trend. ...
<p>(A1) H&E staining of liver sections from wild-type fish revealed normal histology at 11 months. (...
SUMMARY Myc is a pleiotropic transcription factor that is involved in many cellular activities relev...
<p>(A) Immunohistochemical analysis of <i>src</i> protein expression in hepatocytes from the GFP-mC ...
<p>Immunohistochemical analyses of phosphorylated erk1/2 (p-erk), phosphorylated akt (p-akt), myc, v...
<p>(<b>A-C</b>) Control 4-month-old zebrafish showing the liver (L, outlined) positioned in the body...
Liver is the largest organ in the human body, and it regulates many physi-ological processes. Many s...
Hepatocarcinogenesis is a multistep process that starts from fatty liver and transitions to fibrosis...
[[abstract]]Hepatocarcinogenesis is a multistep process that starts from fatty liver and transitions...
Hepatocarcinogenesis is a multistep process that starts from fatty liver and transitions to fibrosis...
[[abstract]]The primary type of liver cancer, hepatocellular carcinoma (HCC), has been associated wi...
[[abstract]]Aflatoxin B1 (AFB1) and the hepatitis B virus X antigen (HBx) are linked to the formatio...
[[abstract]]Liver is the largest organ in the human body, and it regulates many physiological proces...
SUMMARY Human liver cancer is one of the deadliest cancers worldwide, with hepatocellular carcinoma ...
<div><p>Hepatocellular carcinoma (HCC) is currently one of the top lethal cancers with an increasing...
Hepatocellular carcinoma (HCC) is currently one of the top lethal cancers with an increasing trend. ...
<p>(A1) H&E staining of liver sections from wild-type fish revealed normal histology at 11 months. (...
SUMMARY Myc is a pleiotropic transcription factor that is involved in many cellular activities relev...
<p>(A) Immunohistochemical analysis of <i>src</i> protein expression in hepatocytes from the GFP-mC ...
<p>Immunohistochemical analyses of phosphorylated erk1/2 (p-erk), phosphorylated akt (p-akt), myc, v...
<p>(<b>A-C</b>) Control 4-month-old zebrafish showing the liver (L, outlined) positioned in the body...
Liver is the largest organ in the human body, and it regulates many physi-ological processes. Many s...