<p>The cumulative frequency of transgenic fish from multiple lines with chronic inflammation (A), steatosis (B), bile duct dilation (C), hyperplasia (D), dysplasia (E) and HCC (F) were analyzed by Kaplan-Meier analysis. The following different colors denote the different fish lines: black-GFP-mC control, orange-p53 mutant, blue-HBx transgenic fish in wild-type background, red-HBx(p53<sup>-</sup>) transgenic fish, green-src transgenic fish in wild-type background, and purple-src(p53<sup>-</sup>) transgenic fish. P<0.05 was considered to be statistically significant.</p
In fish, microinjection is the method most frequently used for gene transfer. However, due to delaye...
Fish diseases are an indicator for marine ecosystem health since they provide a biological end-point...
Genetic engineering, also called genetic modification, is facing with growing demands of aquaculture...
<p>(A) Lipid metabolism-associated genes, including lipogenic factors, lipogenic enzymes, PPAR-gamma...
<p>(A) Immunohistochemical analysis of <i>src</i> protein expression in hepatocytes from the GFP-mC ...
<p>Twenty-seven <i>GFP-mCherry</i> transgenic fish (as control) and thirty-seven <i>edn1</i> transge...
<p>(A1) H&E staining of liver sections from wild-type fish revealed normal histology at 11 months. (...
<p>(A) Liver fibrosis was determined by Sirius Red staining. (B) Glycogen accumulation was identifie...
<p>MycAG fish were induced by 2 μM mifepristone from 1 mpf and sampled at 7 mpf (6 mpi) for gross ob...
<p>Genes encoding (A) lipogenic factors, (B) lipogenic enzymes, and (C) PPAR-gamma were up-regulated...
<p>The results (75×) from transgenic fish are shown in the upper panels, and wild-type controls with...
<p>MycAG and AG53 fish were induced by 2 μM mifepristone from 1 mpf and sampled at 0.5 mpi and 1.5 m...
Retinoblastoma, a tumor suppressor gene, is frequently mutated in diverse types of human tumors. We ...
Retinoblastoma, a tumor suppressor gene, is frequently mutated in diverse types of human tumors. We ...
The development and potential applications of transgenic fish are described. The expression of a ubi...
In fish, microinjection is the method most frequently used for gene transfer. However, due to delaye...
Fish diseases are an indicator for marine ecosystem health since they provide a biological end-point...
Genetic engineering, also called genetic modification, is facing with growing demands of aquaculture...
<p>(A) Lipid metabolism-associated genes, including lipogenic factors, lipogenic enzymes, PPAR-gamma...
<p>(A) Immunohistochemical analysis of <i>src</i> protein expression in hepatocytes from the GFP-mC ...
<p>Twenty-seven <i>GFP-mCherry</i> transgenic fish (as control) and thirty-seven <i>edn1</i> transge...
<p>(A1) H&E staining of liver sections from wild-type fish revealed normal histology at 11 months. (...
<p>(A) Liver fibrosis was determined by Sirius Red staining. (B) Glycogen accumulation was identifie...
<p>MycAG fish were induced by 2 μM mifepristone from 1 mpf and sampled at 7 mpf (6 mpi) for gross ob...
<p>Genes encoding (A) lipogenic factors, (B) lipogenic enzymes, and (C) PPAR-gamma were up-regulated...
<p>The results (75×) from transgenic fish are shown in the upper panels, and wild-type controls with...
<p>MycAG and AG53 fish were induced by 2 μM mifepristone from 1 mpf and sampled at 0.5 mpi and 1.5 m...
Retinoblastoma, a tumor suppressor gene, is frequently mutated in diverse types of human tumors. We ...
Retinoblastoma, a tumor suppressor gene, is frequently mutated in diverse types of human tumors. We ...
The development and potential applications of transgenic fish are described. The expression of a ubi...
In fish, microinjection is the method most frequently used for gene transfer. However, due to delaye...
Fish diseases are an indicator for marine ecosystem health since they provide a biological end-point...
Genetic engineering, also called genetic modification, is facing with growing demands of aquaculture...