<p>To-scale schematics (<b>A and D</b>), normalized infection data (<b>B and E</b>), and western blotting (<b>C and F</b>) as described for <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1003693#ppat-1003693-g004" target="_blank">Figure 4</a>. Infection data are the geometric mean of at least 4 experiments, with error bars denoting 95% confidence intervals. Inverted grey triangle (panels A and D) denotes area of missense mutation.</p
AbstractTRIM5α is a potent inhibitor of infection by diverse retroviruses and is encoded by one of a...
<p>(A) Percent of WT (gray bar), S224A (backslash), and T225A (horizontal slash) integrations within...
<p><b>A</b>. Lysates from the HEK293 cells that were stably transduced with either pCDH or pCDH-TRIM...
<p>(<b>A</b>) To-scale schematic of NUP153<sub>C</sub> sequences encoded in various Trim-NUP153<sub>...
<p>(<b>A</b>) Pull-down of full-length or quarter deleted HA-NUP153<sub>C</sub> by HIV-1, EIAV, or M...
<p>(<b>A</b>) Schematic of Trim-NUP153<sub>C</sub> fusion and control constructs. Color code: Trim5 ...
<p>Mock transduced and Trim-NUP153<sub>C</sub> expressing (<b>A</b>) or non-targeting control and NU...
<p>The number of available GGs (i.e. mutability) has been used to normalize the results. a) Analysis...
<p>(<b>A</b>) Alignment of residues corresponding to HIV-1 CA Leu56 through Asn74 among various retr...
(a) Representative two-color dot plots of T5KO and control (CAG) Jurkat cells infected first with B2...
<p><b>A</b>. HEK293 cells stably expressing TRIM11 or control pCDH vector were inoculated with 50 ng...
<p>(<b>A</b>) (top) Equal reverse transcriptase (RT) cpm of WT and HIV-1 mutant viruses plated on HO...
(A) Diagram of the different deletion constructs. The ΔRBCC, ΔNHL, and NHL constructs were previousl...
International audienceThrough a screen that combines functional and evolutionary analyses, we identi...
<p>(A) Schematic of the bicistronic lentiviral vector; CMV, immediate early promoter from human cyto...
AbstractTRIM5α is a potent inhibitor of infection by diverse retroviruses and is encoded by one of a...
<p>(A) Percent of WT (gray bar), S224A (backslash), and T225A (horizontal slash) integrations within...
<p><b>A</b>. Lysates from the HEK293 cells that were stably transduced with either pCDH or pCDH-TRIM...
<p>(<b>A</b>) To-scale schematic of NUP153<sub>C</sub> sequences encoded in various Trim-NUP153<sub>...
<p>(<b>A</b>) Pull-down of full-length or quarter deleted HA-NUP153<sub>C</sub> by HIV-1, EIAV, or M...
<p>(<b>A</b>) Schematic of Trim-NUP153<sub>C</sub> fusion and control constructs. Color code: Trim5 ...
<p>Mock transduced and Trim-NUP153<sub>C</sub> expressing (<b>A</b>) or non-targeting control and NU...
<p>The number of available GGs (i.e. mutability) has been used to normalize the results. a) Analysis...
<p>(<b>A</b>) Alignment of residues corresponding to HIV-1 CA Leu56 through Asn74 among various retr...
(a) Representative two-color dot plots of T5KO and control (CAG) Jurkat cells infected first with B2...
<p><b>A</b>. HEK293 cells stably expressing TRIM11 or control pCDH vector were inoculated with 50 ng...
<p>(<b>A</b>) (top) Equal reverse transcriptase (RT) cpm of WT and HIV-1 mutant viruses plated on HO...
(A) Diagram of the different deletion constructs. The ΔRBCC, ΔNHL, and NHL constructs were previousl...
International audienceThrough a screen that combines functional and evolutionary analyses, we identi...
<p>(A) Schematic of the bicistronic lentiviral vector; CMV, immediate early promoter from human cyto...
AbstractTRIM5α is a potent inhibitor of infection by diverse retroviruses and is encoded by one of a...
<p>(A) Percent of WT (gray bar), S224A (backslash), and T225A (horizontal slash) integrations within...
<p><b>A</b>. Lysates from the HEK293 cells that were stably transduced with either pCDH or pCDH-TRIM...