Impaired <i>S. mansoni</i> development in RAG^−/− mice correlates with maintenance of IL-1β transcription.

<p>(A and B) Groups of wild type (A) and RAG^−/− mice (B) were infected percutaneously with <i>S. mansoni</i> cercariae, euthanized at the indicated time points and spleens removed for analysis of IL-1β mRNA levels by real-time PCR. Horizontal bars represent mean values for each experimental group. For wild type mice (A), <i>P</i> values were calculated by ANOVA with Tukey's post-test. For RAG^−/− mice (B), <i>P</i> value was calculated using the Mann Whitney test. (C) Length of male worms and (D) liver egg burdens from <i>S. mansoni</i>-infected RAG^−/− and RAG^−/− IL-1R^−/− mice at 6 weeks p.i. Horizontal bars represent mean values for each experimental group. <i>P</i> values were determined using student's T-test with Welch's correction and the Mann Whitney test. Dashed line in C indicates the average length of male <i>S. mansoni</i> worms recovered from wild type mice at day 42 post infection (3.9 mm).