Survival of nude mice with SK-N-BE(2) neuroblastoma xenografts treated with M002 and repeated XRT.

<p>Established SK-N-BE(2) right flank xenografts (N=25) were treated with vehicle (50 μL) or M002 (1 × 10⁴ PFU/50 μL) and low dose ionizing radiation (XRT) (3 Gy) at Day 0. Subsequent low doses of XRT (3 Gy) were given at 7 day intervals (black arrows) to all vehicle treated animals (n=5); the M002 treated animals were divided into four groups (n=5 per group) to receive either no further treatment or an additional 1, 2, or 3 doses of low dose XRT at 7 day intervals (black arrows). Three surviving animals, all in the M002 XRT × 4 regimen were euthanized at 53 days, with small mean tumor volume (450 ± 131.1 mm³). The mean survival time increased with each subsequent dose of XRT, reaching statistical significance after four doses. M002 with XRT at all groups showed a survival advantage over vehicle with subsequent doses of XRT.