Genes showing consistent differential expression with progression.

<p>Colors on the heatmap represent relative expression values of genes in different phenotypes. The vertical axis lists the differentially expressed genes and the horizontal axis lists the phenotypes. All expression values are normalized as the percentage of maximum expression value for the gene across all phenotypes. For the up-regulated genes in panel <b>A)</b> the maximum expression is either sGBM or pGBM, so we see all genes have brightest color in these two phenotypes; similarly the down-regulated genes in panel <b>B)</b> decrease their expression systematically from normal to GBM, and the intensity level also increases with grade.