miRNA expression profiles in the dentate gyrus of epileptic and sham-operated control animals at different times after SE.

<p>(<b>A</b>) Principle Component Analysis (PCA) of microarray data derived from epileptic (red) and sham-operated control animals (blue) at 7 d (square), 14 d (circle), 30 d (triangle), and 90 d (cross) after status epilepticus. Each mark represents an individual animal. Note that epileptic animals are separate from the controls. (<b>B</b>) A heatmap of the 66 miRNAs with altered expression levels in epileptic animals (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0076051#pone-0076051-t001" target="_blank">Table 1</a>). Each column represents an individual animal and each row represents an individual miRNA. Colors on the heatmap represent the Z-score: higher – red, lower – green. Red color in the bar over the heatmap panel represents epileptic animals, and blue represents sham-operated control animals.