Sternum and kidneys are abnormal in <i>Fras1<sup>bfb/bfb</sup></i> embryos.
- Kerry A. Miller (111238)
- Christopher T. Gordon (384684)
- Megan F. Welfare (451940)
- Georgina Caruana (287073)
- John F. Bertram (287074)
- John F. Bateman (108396)
- Peter G. Farlie (384681)
Publication date
October 2013
DOIAbstract
<p>Sternabrae are misaligned in <i>Fras1<sup>bfb/bfb</sup></i> mice at E18.5 (B), when compared to the sternum of <i>Fras1<sup>+/+</sup></i> embryos of the same age (A). Analysis of the internal organs of <i>Fras1<sup>+/+</sup></i> (C and E) and <i>Fras1<sup>bfb/bfb</sup></i> (D and F) mice show no identifiable kidneys in the majority <i>Fras1<sup>bfb/bfb</sup></i> mutants (asterisk in D). A blood-filled blister is also present in the hindlimb of this embryo (arrowhead in D). Transverse sections of an E17.5 <i>Fras1<sup>bfb/bfb</sup></i> embryo show a large void where the kidney should be located (asterisk in F). A, adrenal gland; K, kidneys.</p
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