Variation of most influential model parameters.

<p>Double-logarithmic plots of cell contact radius versus time. (<b>a</b>) varying cell-substrate adhesion strength yields both a shift in speed and final contact radius. (<b>b</b>) varying the FENE stretching constant yields different final contact radii, (<b>c</b>) varying the FENE max strain also mostly influences the final contact radii, (<b>d</b>) varying bending stiffness influences both spreading speed and final contact radius, (<b>e</b>) varying the normal friction coefficient influences spreading speed and (<b>f</b>) varying the local area constraint constant influences the final spreading radius. For a comparison of spreading rates, see supplementary <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1003267#pcbi.1003267.s001" target="_blank">Figure S1</a>.