Transcriptional expression of cardiac development-related transcription factors in cardiac progenitor cells after lentivirus transfeciton with Islet-1 RNAi.

<p>Quantitative RT-PCR analysis showed the mRNA level for Islet-1 was dramatically reduced in cardiac progenitor cells when transfected with Islet-1 RNA interference vector to inhibit Islet-1 (A). The mRNA levels for Mef2c and Tbx5 were significantly reduced in the cells when Islet-1 expression was inhibited with RNAi as compared with the controls. There was no significant difference in GATA4 mRNA level in the cells with Islet-1 knockdown with RNAi (B). *<i>p</i> < 0.05, n=3-5.