Toward Analogues of MraY Natural Inhibitors: Synthesis of 5′-Triazole-Substituted-Aminoribosyl Uridines Through a Cu-Catalyzed Azide–Alkyne Cycloaddition

A straightforward strategy for the synthesis of triazole-containing MraY inhibitors has been developed. It involves the sequential introduction of a terminal alkyne at the 5′ position of an uridine derivative and <i>O</i>-glycosylation with a protected aminoribose leading to an elaborated alkyne scaffold. An efficient Cu­(I)-catalyzed azide–alkyne cycloaddition (CuAAC) allowed the introduction of chemical diversity toward a small library of inhibitors