Effects of the atypical neuroleptic aripiprazole on ICSS and locomotor behavior in wild type (WT, <i>white</i><i>circles</i>) and <i>Fmr1</i>^-/Y mice (red circles).

<div><p>Changes in BSR threshold (<b>A</b>) and maximum operant response rate (MAX, <b>B</b>) 46-60 minutes after i.p. aripiprazole injections are shown. Values are expressed as mean percentages of pre-injection baselines ± SEM. </p> <p>Asterisks (*) indicate <i>p</i> < 0.05 vs. vehicle (V). <b>C</b>. Mean distance traveled (± SEM) before and after injection of vehicle (VEH) or aripiprazole (ARI, 0.1 mg/kg i.p.) in 15-minute intervals. Shading indicates post-injection time points. <b>D</b>. Mean change in locomotion (± SEM) as a percentage of pre-injection baseline activity for 60 minutes after injection of vehicle (VEH) or aripiprazole (ARI, 0.1 mg/kg i.p.).</p>