Wound healing and Wnt signaling varies with the hair cycle.

<p>On post-wound day 1, H&E staining of injury sites created in (A) anagen or (B) telogen. Post-wound day 2, (C) H&E staining of anagen (D) versus telogen wounds. Dotted yellow line indicates the healing tongue. Post-wound day 3, (E) H&E staining of anagen (F) versus telogen wounds. Dotted yellow line indicates regenerating epithelium. Post-wound day 4, (G) H&E staining of anagen (H) versus telogen wounds. (I) Percentage of healed wounds expressed as a function of the hair cycle (N = 20 per phase). (J) X-Gal staining of a wound bed in anagen versus (K) telogen. Dotted yellow line indicates auricular cartilage. (L) Hair follicles adjacent to the wound edges, in anagen versus (M) telogen. All mice were male. Abbreviations: we, wound edge; re, regenerating epithelium; es, eschar. Scale bar = 50 µm; asterisk denotes P<0.05.