Sub-angstrom accuracy in blind structure prediction of protein loops.

<p>Each panel overlays the best of five lowest energy models from stepwise assembly (SWA; carbon atoms in pink) on the crystallographic loop (blue). The build-up path that gave the SWA model is shown as a dynamic-programming-style matrix (black arrows mark single-residue additions; gray arrow marks chain closure step). (<b>a</b>–<b>d)</b> Recovery of loops of an unreleased structure of 275-residue protein with all loops and all side-chains removed, with Cα RMSDs of 0.91 Å, 0.91 Å, 0.54 Å, 0.52 Å. (<b>e</b>) <i>3v7e</i> RNA-puzzle (RMSD 0.54 Å), with RNA component shown in green.