Noscapine (1) and its analogues 6f-h inhibit cell cycle progression at mitosis followed by the appearance of a characteristic hypodiploid (sub-G1) DNA peak, indicative of apoptosis.

<p>Panels A-C depict analyses of cell cycle distribution in a two-dimensional disposition as determined by flow cytometry in MCF-7 cells treated with 25 µM of noscapine (1), <b>6f, 6g</b>, and <b>6h</b> for 0, 24 and 72 hours, respectively.