Learning performance in the Morris water maze.

<p>Mice of all three genotypes (5-HTT+/+, 5-HTT+/-, 5-HTT-/-) were tested three times per day for 4 consecutive days (acquisition phase; trials 1 - 12). Trials on day five represent reversal trials (trials 13-15). (A) Learning curve for the latency to find the platform. RM-ANOVA revealed a significant effect of trial (indicating learning performance) and a significant genotype effect. (B) The area under the learning curve (AuC) was calculated for each individual for statistical comparison of learning in the acquisition phase. ANOVA revealed a significant effect of genotype. Post hoc analysis using Bonferroni corrected t-tests revealed significant differences between 5-HTT-/- and both other genotypes. (C) Curve depicting the number of stops for each trial. RM-ANOVA revealed a significant effect of trial and genotype. (D) The AuC for the number of stops revealed a significant effect of genotype. Post hoc analysis using Bonferroni corrected t-tests revealed significant differences between 5-HTT-/- and both other genotypes. Data in all figures represent means + SEM. ***=p<0.001.