P1736 acts as a potent <i>in</i><i>vitro</i> insulin sensitizer.

<p><b>a</b>, Chemical structure of P1736. <b>b</b>, Insulin stimulated glucose uptake in normal adipocytes(empty bar), insulin resistant adipocytes(solid bar) and insulin resistant adipocytes treated with rosiglitazone (bar with stripes). <b>c</b>, Glucose uptake in the dexamethasone - induced insulin resistant adipocytes exposed to vehicle(empty bar) or P1736 (10 µM, solid bar). <b>d</b>, Glucose uptake in the dexamethasone-induced insulin resistant adipocytes exposed to vehicle (empty bar) or metformin (1.0mM, bar with stripes). <b>e</b>, Dose response of P1736 on glucose uptake in dexamethasone - induced insulin resistant adipocytes. Data are expressed as Mean ± SEM. Difference between vehicle and treatment groups were statistically evaluated by t-test., ^#p<0.01 compared to normal adipocytes, **p<0.01 compared to insulin resistant adipocytes (vehicle).