Resveratrol induces redistribution of PI [3], [4], [5]P₃ reporter GFP-AKT-PH in mpkCCD_c14 cells.

<p>Cultured mpkCCD_c14 cells were transfected with GFP-AKT-PH and examined by live-cell epifluorescence microscopy. Addition of resveratrol (<i>upper panels</i>) caused a rapid redistribution of PI <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0078019#pone.0078019-Shimkets1" target="_blank">[3]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0078019#pone.0078019-Hansson1" target="_blank">[4]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0078019#pone.0078019-Chang1" target="_blank">[5]</a>P₃ from the plasma membrane whereas control-treated cells showed little change (<i>lower panels</i>). Representative data are shown from four independent trials and representative of identical observations.