IL-10^−/− mice clear <i>P. brasiliensis</i> infection and develop mild pulmonary inflammatory reactions.

<p>Photomicrographs of lungs, livers and spleens from WT (A to F) and IL-10^−/− (G to L) mice at week 8 after infection with 1×10⁶<i>P. brasiliensis</i> yeast cells. Compared with IL-10^−/− mice, increased number of inflammatory cells and more severe lesions were detected in WT mice. For panels: A, C, E, G, I and K, HE-stained, magnification ×10; for B, D, F, H, J and L, Groccot-stained, magnification ×10. Morphometrical analysis (M) confirmed the more extensive areas occupied by the lung and liver lesions of WT mice (*** <i>p</i><0.001).