Comparative bioinformatics analysis of genes coding components of vesicle-mediated trafficking and endosomal sorting in apicomplexan parasites, <i>Saccharomyces cerevisiae</i>, and <i>Homo sapiens</i>.

<p>Most of these genes and their corresponding accession numbers were collected from Eupathdb.org (for apicomplexan parasites) and uniprot.org (yeast and human cells). The data from apicomplexan parasites <i>Toxoplasma gondii</i> (<i>T. gondii</i>), <i>Plasmodium falciparum</i> (<i>P. falciparum</i>), <i>Theileria parva</i> (<i>T. parva</i>), and <i>Cryptosporidium parvum</i> (<i>C. parvum</i>) were compared with human (<i>H. sapiens</i>) and the yeast <i>Saccharomyces cerevisiae</i> (<i>S. cerevisiae</i>). AP, adaptor protein; GGAs, Golgi-localized, γ-ear–containing, ADP-ribosylation factor binding protein; COPI, Coatomer complex I (retrograde transport from trans-Golgi apparatus to cis-Golgi and endoplasmic reticulum); COPII, Coatomer complex II (anterograde transport from ER to the cis-Golgi); ESCRT, Endosomal Sorting Complex Required for Transport.