<i>In</i><i>vivo</i> selection of public TCR clonotypes in healthy donors and melanoma patients.

<p><b>A</b>. Compilation of the 14 public amino acid TCR beta-domain sequences detected among three healthy individuals and five melanoma patients. Each TCR beta-chain clonotype is described by the TRBV segment, CDR3-beta sequence, TRBJ segment, number of nucleotide sequence variants identified for each amino acid sequence, as well as the proportion of healthy donors and patients from which each sequence was identified. <b>B</b>. Distribution of public sequences within the overall EBV-specific CD8 T cells in healthy donors and patients according to their relative frequency; dominant clonotypes (with frequency >5%) are represented in black, low dominant (1-5%) in grey and unique sequences in white.