Obesity and adiposity in male and female high fat fed 3xTg-AD mice.

<p>A, Body weight in male and female 3xTg-AD mice across the 4 month feeding period. B, Percent change in body weight relative to baseline weight after 4 months of feeding with either standard or high fat diet. C, Abdominal retroperitoneal fat pad weight in male (solid bars) and female (open bars) 3xTg-AD mice. D, Representative images of hematoxylin-stained livers in male and female mice fed regular and high fat diets. E, Quantification of microvesicular (<15 µm) and macrovesicular (>15 µm) fat accumulation in liver. F. Serum testosterone and estradiol levels in male and female mice respectively. Data presented as mean ± SEM.† <i>p</i><0.001 relative to matched time point males fed regular diet. ‡<i>p</i><0.001 relative to matched time point females with regular diet. **<i>p</i><0.001 relative to regular diet fed mice. *<i>p</i><0.01 male versus female mice. γ<i>p</i><0.05 relative to sex-matched regular diet fed mice.