ATRA up-regulated CRE-dependent mouse ORMDL3 promoter transcriptional activity in NIH3T3 cells.

<p>(A) Schematic diagram of the mouse ORMDL3 gene core promoter-driven luciferase plasmid pGL3-74 and CRE-element deletion mutation plasmid del-CRE. (B) ATRA increased ORMDL3 promoter (pGL3-74) activity, and this increase could be weakened by endogenous CREB knockdown or CREB-binding site deletion. Relative luciferase activity of pGL-74 co-transfected with control siRNA stimulated with DMSO was set as 1. Data represent the mean ± SE of triplicate experiments (*<i>P</i><0.05 vs. control).