Inhibitory network tunes the frequency of oscillatory activity.

<p>A: sIPSCs and sEPSCs from GCs at different conditions. Gradual removal of distinct components of inhibitory network tunes the frequency of BC-driven oscillatory activity in GC. Blockade of glycine (strychnine) and GABA_ARs (SR-95531 or bicuculline) shaped the oscillatory activity into high-frequency and low-amplitude events. The removal of slow inhibitory inputs mediated by GABA_CRs (TPMPA) shaped the oscillator into low-frequency and high-amplitude mode. B: A representative whole-cell sEPSC recording from a GC showing a gradual transition during a blockade of ‘fast’ and ‘slow’ components of inhibitory inputs. C: Response spectrogram illustrating transition in power and frequency profiles of BC output FFT power for GC shown in B. Blue to red transition depicts increase in FFT power at specified frequency domain during different pharmacological conditions.