Inactivation of <i>Rgs6</i> disrupts cardiac rhythm in mice.
- Ekaterina Posokhova (477690)
- David Ng (266907)
- Aaisha Opel (477691)
- Ikuo Masuho (477692)
- Andrew Tinker (477693)
- Leslie G. Biesecker (477694)
- Kevin Wickman (477695)
- Kirill A. Martemyanov (477696)
Publication date
October 2013
DOIAbstract
<p>A, Representative tachograms of RR intervals from wild-type (black) and <i>Rgs6<sup>−/−</sup></i> (red) mice recorded by ECG radiotelemetry. B and C, Summary of HRV analysis in conscious, freely-moving mice. D, Burst pacing induced AF in <i>Rgs6<sup>−/−</sup></i> but not in wild-type mice. Note an irregular rhythm with no discernible P waves in the <i>Rgs6<sup>−/−</sup></i> recording. E, Quantification of AF induction probability. Symbols: *, P<0.05.</p
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