<p>The case of symmetrically dividing stem cells, same as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0076195#pone-0076195-g005" target="_blank">Figure 5</a>.</p
<p>Plotted is the quantity in formula (4) as a function of the mutation rate, . The percentage of th...
Stem cell divisions are either asymmetric-in which one daughter cell remains a stem cell and one doe...
Stem cell divisions are either asymmetric—in which one daughter cell remains a stem cell and one doe...
<p>The results of numerical simulations are presented as points connected with dotted lines (standar...
<p>As in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0076195#pone-0076195-...
Traditionally, it has been held that a central characteristic of stem cells is their ability to divi...
Traditionally, it has been held that a central characteristic of stem cells is their ability to divi...
<p>(A) Homeostasis of stem cell number may be achieved by invariant asymmetric renewals. (B) Alterna...
<p>(A) A fraction <i>s</i> of stem cells divide symmetrically while the others divide asymmetrically...
<p>The weight of a typical symmetrically dividing mutant stem cell lineage, , relative to the weight...
<p>The quantity , which corresponds to , is plotted as a function of the mutation rate, , for three ...
<p>The fastest pathway of both cases is DGR, but the probabilities of stem-cell division are markedl...
<p>Assumptions as to the number of symmetric (<i>n</i><sub>1</sub>) and asymmetric cell divisions (<...
<p>The probability of double-hit mutant generation is calculated for a particular set of parameters ...
Most tissues in metazoans undergo continuous turnover due to cell death or epithelial shedding. Sinc...
<p>Plotted is the quantity in formula (4) as a function of the mutation rate, . The percentage of th...
Stem cell divisions are either asymmetric-in which one daughter cell remains a stem cell and one doe...
Stem cell divisions are either asymmetric—in which one daughter cell remains a stem cell and one doe...
<p>The results of numerical simulations are presented as points connected with dotted lines (standar...
<p>As in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0076195#pone-0076195-...
Traditionally, it has been held that a central characteristic of stem cells is their ability to divi...
Traditionally, it has been held that a central characteristic of stem cells is their ability to divi...
<p>(A) Homeostasis of stem cell number may be achieved by invariant asymmetric renewals. (B) Alterna...
<p>(A) A fraction <i>s</i> of stem cells divide symmetrically while the others divide asymmetrically...
<p>The weight of a typical symmetrically dividing mutant stem cell lineage, , relative to the weight...
<p>The quantity , which corresponds to , is plotted as a function of the mutation rate, , for three ...
<p>The fastest pathway of both cases is DGR, but the probabilities of stem-cell division are markedl...
<p>Assumptions as to the number of symmetric (<i>n</i><sub>1</sub>) and asymmetric cell divisions (<...
<p>The probability of double-hit mutant generation is calculated for a particular set of parameters ...
Most tissues in metazoans undergo continuous turnover due to cell death or epithelial shedding. Sinc...
<p>Plotted is the quantity in formula (4) as a function of the mutation rate, . The percentage of th...
Stem cell divisions are either asymmetric-in which one daughter cell remains a stem cell and one doe...
Stem cell divisions are either asymmetric—in which one daughter cell remains a stem cell and one doe...
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