<p>(<b>A</b>) The inhibition of LANA on CIITA promoter is independent on IL-4 or IFNγ-induced signaling.HEK293 cells were co-transfected pA3M-LANA with pIII or pIV luciferase reporter as indicated in the figure. At 24 hr post-transfection, cells were treated with IL-4 (20 ng/ml), IFNγ (400 ng/ml) or untreated for 36 hours, followed by reporter assays. (<b>B</b>) Expression of IRF-4 in KSHV negative B lymphoma and positive PEL cells. Immunoblotting (IB) analysis was performed using 100 µg of whole-cell lysates from KSHV negative B lymphoma (DG75, Ramos and BJAB) and positive PEL (BC3, BCBL1, JSC1) cell lines. Immunoblots were probed with anti-IRF-4 antibody. The membrane was reblotted with anti-GAPDH antibody to verify protein-loading homoge...
<p>(<b>A</b>) IRF-4 binds to C-terminal domain of LANA <i>in vitro</i>. The <sup>35</sup>S-radiolabe...
<p>(A) The murine IP-10 promoter contains a putative GAS-like element (underlined). (B) NIH3T3 cells...
The interferon regulatory factors (IRF) are a family of transcription factors that control intrinsic...
<p>(<b>A</b>) The level of CIITA expression was reduced by LANA in a dose-dependent manner. Ten mill...
<p>(<b>A</b>) Schematic of pIL22R1 (−2139 to +39) and a series of deletion mutants (pIL22R1-D1, D2, ...
Peptides presentation to T cells by MHC class II molecules is of importance in initiation of immune ...
<p>(<b>A</b>) The relative levels of CIITA pIII and pIV transcripts in PEL cells with LANA or contro...
<p>In the KSHV-infected cells, the major latent antigen LANA interacts with IRF-4 and reduces the DN...
<p>(<b>A</b>) Intact or cleaved form of STAT6 bound to RTA promoter and enhanced by LANA. HEK293 cel...
<p>(<b>A</b>) Schematic of pIL22R1 (−2139 to +39), pIL22R1ΔLBS-like and pIL22R1mLBS-like DNA sequenc...
AbstractPim kinases are proto-oncogenes that are upregulated in a number of B cell cancers, includin...
<p>The −2 Kb promoter regions of individual viral genes were PCR amplified and cloned upstream of Lu...
<p>(<b>A</b>) Schematic diagram showing the locations of the two pairs of primers used in the ChIP a...
<div><p>Kaposi's sarcoma-associated herpesvirus (KSHV) is a γ-herpesvirus associated with KS and two...
<p>(<b>A</b>) Inhibition of LANA blocks nuclear localization of STAT6. Confocal microscopy of endoge...
<p>(<b>A</b>) IRF-4 binds to C-terminal domain of LANA <i>in vitro</i>. The <sup>35</sup>S-radiolabe...
<p>(A) The murine IP-10 promoter contains a putative GAS-like element (underlined). (B) NIH3T3 cells...
The interferon regulatory factors (IRF) are a family of transcription factors that control intrinsic...
<p>(<b>A</b>) The level of CIITA expression was reduced by LANA in a dose-dependent manner. Ten mill...
<p>(<b>A</b>) Schematic of pIL22R1 (−2139 to +39) and a series of deletion mutants (pIL22R1-D1, D2, ...
Peptides presentation to T cells by MHC class II molecules is of importance in initiation of immune ...
<p>(<b>A</b>) The relative levels of CIITA pIII and pIV transcripts in PEL cells with LANA or contro...
<p>In the KSHV-infected cells, the major latent antigen LANA interacts with IRF-4 and reduces the DN...
<p>(<b>A</b>) Intact or cleaved form of STAT6 bound to RTA promoter and enhanced by LANA. HEK293 cel...
<p>(<b>A</b>) Schematic of pIL22R1 (−2139 to +39), pIL22R1ΔLBS-like and pIL22R1mLBS-like DNA sequenc...
AbstractPim kinases are proto-oncogenes that are upregulated in a number of B cell cancers, includin...
<p>The −2 Kb promoter regions of individual viral genes were PCR amplified and cloned upstream of Lu...
<p>(<b>A</b>) Schematic diagram showing the locations of the two pairs of primers used in the ChIP a...
<div><p>Kaposi's sarcoma-associated herpesvirus (KSHV) is a γ-herpesvirus associated with KS and two...
<p>(<b>A</b>) Inhibition of LANA blocks nuclear localization of STAT6. Confocal microscopy of endoge...
<p>(<b>A</b>) IRF-4 binds to C-terminal domain of LANA <i>in vitro</i>. The <sup>35</sup>S-radiolabe...
<p>(A) The murine IP-10 promoter contains a putative GAS-like element (underlined). (B) NIH3T3 cells...
The interferon regulatory factors (IRF) are a family of transcription factors that control intrinsic...