Association between polygene score and LDLc measured at age nine in the ALSPAC cohort.

<p>Association between polygene score and LDLc measured at age nine using different p-value thresholds for the construction of the score in ALSPAC children (N = 4251). The lines joining the circles display the results for allelic scores calculated by using genotyped variants from across the genome in either a weighted (unbroken line) or an unweighted (dashed line) fashion. The lines joining the triangles display scores calculated similarly but excluding all variants +/−1 MB around 37 known LDLc variants, and using either a weighted (unbroken line) or unweighted (dashed line) strategy. The histogram in the background displays the number of SNPs involved in construction of the allelic score at each corresponding SNP inclusion threshold for the “All variants” condition.