The modular landscape of Intellectual Disability.

<p>Graphic summary of ID genes, phenotypes and features identified in this study. Note the consistent asymmetry of features among EMD- versus NED-ID genes in these datasets. From the periphery to the centre: segment <b>1.</b> Human gene symbols and reported genetic interactions. <b>2.</b> Major phenotype classes: EMD (in red), ERG defective (in orange), NED (in blue) and lethal (in brown) phenotypes. <b>3.</b> EMD categories. Rough (R), mildly rough (MR), long bristles (LoB), (partially) fused ommatidia (F), stubble bristles (SB), fewer bristles (FB), no bristles (NB), small eye, wrinkled/dented surface (SEWDS), loss of pigmentation (P), necrosis (NEC). <b>4.</b> Black squares: human postsynaptic density proteins (listed in <b><a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003911#pgen.1003911.s008" target="_blank">Table S3</a></b>). <b>5.</b> Pink squares: genes with their highest relative expression in nerve tissue (see also <b><a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003911#pgen.1003911.s002" target="_blank">Figure S2A</a></b>). <b>6.</b> Human phenotype ontology features (from HPO database, see <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003911#s4" target="_blank">Materials and Methods</a>). Red: enriched for Head-Neck/Musculoskeletal features, green: enriched for metabolism, yellow: enriched for both terms. <b>7.</b> Significantly enriched phenotypes from FlyBase. Purple color represent nervous system related phenotypic terms (neuroanatomy, neurophysiology and photoreceptor) whereas turquoise color represents stress response phenotypes. Dark grey: both enriched. <b>8.</b> ID genes that contribute to enriched neuronal functions among EMD-ID genes (in red) and enriched metabolic process among NED-ID genes (in green). See <b><a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003911#pgen.1003911.s002" target="_blank">Figure S2C</a>,D</b> for a the underlying GO terms. <b>9.</b> Protein-protein interactions (PPI). PPIs within EMD-, NED-ID and lethal gene products are represented as red, blue and brown colored lines, respectively. Grey lines represent PPI links between EMD or lethal to NED gene products.