<i>Mlh1</i> is an enhancer of nuclear mutant huntingtin immunostaining in B6.<i>Hdh<sup>Q111/+</sup></i> mice.
- Ricardo Mouro Pinto (207712)
- Ella Dragileva (136558)
- Andrew Kirby (47075)
- Alejandro Lloret (478554)
- Edith Lopez (160236)
- Jason St. Claire (136559)
- Gagan B. Panigrahi (478555)
- Caixia Hou (478556)
- Kim Holloway (478557)
- Tammy Gillis (21924)
- Jolene R. Guide (136560)
- Paula E. Cohen (218889)
- Guo-Min Li (31057)
- Christopher E. Pearson (263866)
- Mark J. Daly (210204)
- Vanessa C. Wheeler (136566)
Publication date
October 2013
DOIAbstract
<p>(A) Representative EM48 immunostained histological sections from striata of 22-week-old B6.<i>Hdh<sup>Q111/+</sup></i> mice on different <i>Mlh1</i> genetic backgrounds. <i>Mlh1<sup>+/+</sup></i>, CAG113; <i>Mlh1<sup>+/−</sup></i>, CAG108; <i>Mlh1<sup>−/−</sup></i>, CAG110. (B) Quantification of diffuse nuclear EM48 staining demonstrates a statistically significant reduction in the absence of <i>Mlh1</i>. <i>Mlh1<sup>+/+</sup></i>, CAG115.3±4.9SD, <i>n</i> = 6; <i>Mlh1<sup>+/−</sup></i>, CAG112.0±2.1SD, <i>n</i> = 6; <i>Mlh1<sup>−/−</sup></i>, CAG109.2±2.9SD, <i>n</i> = 5. Bar graphs represent mean ±SD. **, <i>p</i><0.01.</p
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