Lipid metabolism in offspring of maternal WSD represented by sub-functions and heat maps.

<p>(A) and (B) display sub-functions of lipid-metabolism that were according to IPA significantly regulated (<i>p</i>≤0.05) upon maternal WSD in males or females respectively and contained≥7 regulated molecules. Hatched bars = sub-functions that are regulated in both sexes. Filled bars = sub-functions that are specific for the sex. Syn = Synthesis; Conc = Concentration; Metab = Metabolism; Transp = Transport; Accu = Accumulation; Terp = Terpenoid; Cho = Cholesterol; DAG = Diacylglycerol; FA = Fatty Acid. (C) and (D) show hierarchical clustered heat maps of the fatty acid metabolism gene set and the cholesterol metabolism gene set, respectively. Hierarchical clustering of gene sets was based on Pearson correlation. Gene expression values are displayed on colour scale: blue indicates lower values than average of maternal LFD-group of respective sex; orange indicates higher values than average of maternal LFD-group of respective sex. (m) = gene was significantly changed in male offspring upon maternal WSD. (f) = gene was significantly changed in female offspring upon maternal WSD. <i>p</i>-values≤0.01 were considered significant.