Dimeric interface of the structure of CARMA1 CARD.

<p>A. The dimeric structure of CARMA1 CARD and close-up view of the interacting residues in the interface between dimers (cyan for chain B and green for chain A). The residues involved in the contact are shown as cyan (from chain B) and green (from chain A) sticks. Hydrogen bonds formed between E27 from one chain and H31 from counterpart are shown as dashed lines. The disulfide bond formed by C28 from chain A and C28 from chain B is shown as a black dashed-circle. B. Close-up view of the disulfide bond between C28 (chain A) and C28 (chain B). The electron density map is shown as a gray color mesh. C. Conserved cysteine residue involved in the disulfide bond. The conserved cysteine residue cross species is highlighted by red color. Perfectly conserved residues are shown in black and residues that are not perfectly conserved are blue.