Fhit overexpression and paclitaxel treatment induces synergistic proliferation inhibition.

<p><b>A-B</b>. A549 and Calu-2 cells were mock-infected, Ad<i>GFP</i> or Ad<i>FHIT</i> infected cells at MOI10 for 24 h, then treated with or without 800 nM paclitaxel for additional 6 h and counted. Bar graphs show mean ± SEM for values from three different experiments (* P<0,05). The Chou-Talalay methos was applied to calculate the nature of the combinations (CI<1, synergism). <b>C</b>. A549 cells were either mock-infected or infected with Ad<i>GFP</i> or Ad<i>FHIT</i>, or left untreated or treated with 800 nM paclitaxel, and then analyzed by flow cytometry.