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BGN mRNA expression is increased in muscle invasive and in high-grade tumors.

  • Christian Niedworok (459826)
  • Katharina Röck (459828)
  • Inga Kretschmer (459827)
  • Till Freudenberger (459832)
  • Nadine Nagy (480777)
  • Tibor Szarvas (459830)
  • Frank vom Dorp (459829)
  • Henning Reis (480778)
  • Herbert Rübben (459834)
  • Jens W. Fischer (459835)
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Publication date
November 2013
Icon DOI
10.1371/journal.pone.0080084.g001

Abstract

<p>BGN mRNA was investigated in 76 patients with bladder cancer by RT-qPCR and compared to non-malignant bladder tissue. A significant elevation of BGN mRNA expression was detected in muscle-invasive compared to non-invasive tumors (<b>A</b>) and in high-grade compared to low-grade tumors (<b>B</b>). Furthermore, BGN mRNA expression correlated with increasing tumor stage (<b>C</b>). n=76 patients, *<i>p</i><0.05, ***<i>p</i>=0.0003.</p

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