MCPIP1 deficiency increased macrophage cholesterol efflux.

<p><b>A</b>. Bone marrow-derived macrophages were loaded with ac-LDL and cholesterol efflux to DMEM, apoAI and HDL was measured. Data were presented as mean ± SEM. N = 3 in each group. <b>B</b>. Bone marrow-derived macrophages were cultured in DMEM for 48 h with or without ac-LDL. Cell lysates were used for western blotting analysis for ABCA1 and ABCG1. Representative western blotting result was shown. <b>C</b>. Quantitative analysis of the western blots. Data were presented as mean ± SEM. N = 4 in each group. Open column: WT macrophages; Black column, MCPIP1−/− macrophages.