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Bone marrow MCPIP1 deficiency dramatically reduced atherosclerotic lesion size in mouse aorta.

Fang Yu (156838)
Fen Du (480786)
Yuzhen Wang (480787)
Shengping Huang (287849)
Ruidong Miao (480788)
Amy S. Major (480789)
E. Angela Murphy (480790)
Mingui Fu (79114)
Daping Fan (441395)

Publication date

November 2013

DOI

10.1371/journal.pone.0080089.g008

Abstract

<p><b>A</b>. Representative atherosclerosis lesions of aortic root. <b>B</b>. Quantification of aortic root atherosclerotic lesion size. <b>C</b>. Representative <i>en face</i> aorta atherosclerosis.</p

Extracted data

Related items

Development of atherosclerotic plaques in LDLR−/− PWT and LDLR−/−PKO mice fed LFD and HFD.

Tanja Steiner (542397)
Lorenza Francescut (542398)
Simon Byrne (542399)
Timothy Hughes (56285)
Archana Jayanthi (542400)
Irina Guschina (542401)
John Harwood (93890)
Katherine Cianflone (155973)
Cordula Stover (542402)
Sheila Francis (265603)

March 2014

<p><b>A</b> therosclerosis-prone mice (males and females) lacking properdin were fed low fat or high...

Aortic root atherosclerosis in Paigen diet-fed apoE KO and PDZK1/apoE dKO mice.

Ayce Yesilaltay (368962)
Kathleen Daniels (368963)
Rinku Pal (284735)
Monty Krieger (125581)
Olivier Kocher (158771)

February 2013

<p>Hearts were harvested from Paigen diet-fed apoE KO (A, C–D) and PDZK1/apoE dKO (B, E–F) mice as d...

γδT cell deficiency reduces aortic root lesion area in 24 wk-old chow-fed ApoE KO mice.

Duc M. Vu (644128)
Albert Tai (349165)
Jeffrey B. Tatro (644129)
Richard H. Karas (147803)
Brigitte T. Huber (644130)
Debbie Beasley (644131)

October 2014

<p><b>A&D:</b> Aortic root lipid-rich lesions outlined in <i>green</i> (<i>en face</i> view) are sig...

Bone Marrow Deficiency of MCPIP1 Results in Severe Multi-Organ Inflammation but Diminishes Atherogenesis in Hyperlipidemic Mice

Fang Yu
Fen Du
Yuzhen Wang
Shengping Huang
Ruidong Miao
Amy S. Major
E. Angela Murphy
Mingui Fu
Daping Fan

August 2016

Objective: MCPIP1 is a newly identified protein that profoundly impacts immunity and inflammation. W...

Multi-Organ Inflammation but Diminishes Atherogenesis

Shengping Huang
See Profile
Amy S Major
Daping Fan
Fang Yu
Fen Du
Yuzhen Wang
Shengping Huang
Ruidong Miao
Amy S. Major
E. Angela Murphy
Mingui Fu
Daping Fan

January 2016

Objective: MCPIP1 is a newly identified protein that profoundly impacts immunity and inflammation. W...

Bone marrow MCPIP1 deficiency resulted in growth retardation and lymphadenopathy.

Fang Yu (156838)
Fen Du (480786)
Yuzhen Wang (480787)
Shengping Huang (287849)
Ruidong Miao (480788)
Amy S. Major (480789)
E. Angela Murphy (480790)
Mingui Fu (79114)
Daping Fan (441395)

November 2013

<p><b>A</b>. Representative images of LDLR−/− mice received bone marrow cells from WT (WT) or MCPIP1...

Genetic Backgrounds but Not Sizes of Atherosclerotic Lesions Determine Medial Destruction in the Aortic Root of Apolipoprotein E–Deficient Mice

Weibin Shi
Morry D. Brown
Xuping Wang
Jack Wong
David F. Kallmes
Alan H. Matsumoto
Gregory A. Helm
Thomas A. Drake
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July 2015

Objective—Destruction of the elastic media is the most striking histologic feature of atheroscleroti...

Size and macrophage content of advanced aortic root lesions.

Robert H. Lee (715546)
Guillermo Vazquez (715547)

March 2015

<p>Atherosclerotic lesions in aortic root sections from LDLRKO mice transplanted with bone marrow fr...

Bone marrow MCPIP1 deficiency caused hematological disturbance.

Fang Yu (156838)
Fen Du (480786)
Yuzhen Wang (480787)
Shengping Huang (287849)
Ruidong Miao (480788)
Amy S. Major (480789)
E. Angela Murphy (480790)
Mingui Fu (79114)
Daping Fan (441395)

November 2013

<p><b>A</b>. Giemsa stained blood smears showed MCPIP1−/− bone marrow cell recipients contain dramat...

Analysis of atherosclerosis in the aortic root of bone marrow transplanted LDLr KO mice after 9 weeks of HF/HC diet feeding.

Bart Lammers (302835)
Ying Zhao (16546)
Menno Hoekstra (342164)
Reeni B. Hildebrand (180079)
Dan Ye (180080)
Illiana Meurs (180070)
Theo J. C. Van Berkel (2222029)
Miranda Van Eck (180084)

February 2013

<p>Quantification of atherosclerotic lesion sizes in the aortic root and TC levels in bone marrow tr...

Analysis of atherosclerosis in the aortic arch of bone marrow transplanted LDLr KO mice after 9 weeks of HF/HC diet feeding.

Bart Lammers (302835)
Ying Zhao (16546)
Menno Hoekstra (342164)
Reeni B. Hildebrand (180079)
Dan Ye (180080)
Illiana Meurs (180070)
Theo J. C. Van Berkel (2222029)
Miranda Van Eck (180084)

February 2013

<p>Relative plaque area in the aortic arch was quantified <i>en face</i> calculating the ratio of at...

Atherosclerosis in the aortic root of LDLr KO mice reconstituted with WT, ABCA1 KO, ABCA7 KO and dKO bone marrow.

Illiana Meurs (180070)
Laura Calpe-Berdiel (180072)
Kim L. L. Habets (180074)
Ying Zhao (16546)
Suzanne J. A. Korporaal (180076)
A. Mieke Mommaas (45117)
Emmanuelle Josselin (86865)
Reeni B. Hildebrand (180079)
Dan Ye (180080)
Ruud Out (180081)
Johan Kuiper (128579)
Theo J. C. Van Berkel (2222029)
Giovanna Chimini (180082)
Miranda Van Eck (180084)

March 2012

<p>(<b>A</b>) The mean lesion area (µm<sup>2</sup>) was calculated from Oil red O-stained cross-sect...

Atherosclerosis development with Western Diet Feeding.

Ricardo A. Garcia (4107238)
Mujing Yan (278971)
Debra Search (652729)
Rongan Zhang (278970)
Nancy L. Carson (278978)
Carol S. Ryan (278974)
Constance Smith-Monroy (652730)
Joanna Zheng (652731)
Jian Chen (15340)
Yan Kong (652732)
Huaping Tang (652733)
Samuel E. Hellings (278972)
Judith Wardwell-Swanson (652734)
Joseph E. Dinchuk (652735)
George C. Psaltis (278981)
David A. Gordon (278984)
Peter W. Glunz (652736)
Peter S. Gargalovic (278973)

October 2014

<p>En face plaque quantification of excised mouse aortas using oil red O. <b>A</b>) Lesion area meas...

Bone marrow–derived MCP1 required for experimental aortic aneurysm formation and smooth muscle phenotypic modulation

Moehle, Christopher W.
Bhamidipati, Castigliano M.
Alexander, Matthew R.
Mehta, Gaurav S.
Irvine, James N.
Salmon, Morgan
Upchurch, Gilbert R.
Kron, Irving L.
Owens, Gary K.
Ailawadi, Gorav

December 2011

ObjectivesThis study tested the hypothesis that monocyte chemotactic protein 1 (MCP1) is required fo...

γδT cell deficiency reduces aortic arch lesion area in Western diet-fed ApoE KO mice.

Duc M. Vu (644128)
Albert Tai (349165)
Jeffrey B. Tatro (644129)
Richard H. Karas (147803)
Brigitte T. Huber (644130)
Debbie Beasley (644131)

October 2014

<p>Mice were fed Western diet for 4 weeks and aortic root cross sections were stained with <b>A:</b>...

Development of atherosclerotic plaques in LDLR−/− PWT and LDLR−/−PKO mice fed LFD and HFD.

Tanja Steiner (542397)
Lorenza Francescut (542398)
Simon Byrne (542399)
Timothy Hughes (56285)
Archana Jayanthi (542400)
Irina Guschina (542401)
John Harwood (93890)
Katherine Cianflone (155973)
Cordula Stover (542402)
Sheila Francis (265603)

March 2014

<p><b>A</b> therosclerosis-prone mice (males and females) lacking properdin were fed low fat or high...

Aortic root atherosclerosis in Paigen diet-fed apoE KO and PDZK1/apoE dKO mice.

Ayce Yesilaltay (368962)
Kathleen Daniels (368963)
Rinku Pal (284735)
Monty Krieger (125581)
Olivier Kocher (158771)

February 2013

<p>Hearts were harvested from Paigen diet-fed apoE KO (A, C–D) and PDZK1/apoE dKO (B, E–F) mice as d...

γδT cell deficiency reduces aortic root lesion area in 24 wk-old chow-fed ApoE KO mice.

Duc M. Vu (644128)
Albert Tai (349165)
Jeffrey B. Tatro (644129)
Richard H. Karas (147803)
Brigitte T. Huber (644130)
Debbie Beasley (644131)

October 2014

<p><b>A&D:</b> Aortic root lipid-rich lesions outlined in <i>green</i> (<i>en face</i> view) are sig...

Bone Marrow Deficiency of MCPIP1 Results in Severe Multi-Organ Inflammation but Diminishes Atherogenesis in Hyperlipidemic Mice

Fang Yu
Fen Du
Yuzhen Wang
Shengping Huang
Ruidong Miao
Amy S. Major
E. Angela Murphy
Mingui Fu
Daping Fan

August 2016

Objective: MCPIP1 is a newly identified protein that profoundly impacts immunity and inflammation. W...

Multi-Organ Inflammation but Diminishes Atherogenesis

Shengping Huang
See Profile
Amy S Major
Daping Fan
Fang Yu
Fen Du
Yuzhen Wang
Shengping Huang
Ruidong Miao
Amy S. Major
E. Angela Murphy
Mingui Fu
Daping Fan

January 2016

Objective: MCPIP1 is a newly identified protein that profoundly impacts immunity and inflammation. W...

Bone marrow MCPIP1 deficiency resulted in growth retardation and lymphadenopathy.

Fang Yu (156838)
Fen Du (480786)
Yuzhen Wang (480787)
Shengping Huang (287849)
Ruidong Miao (480788)
Amy S. Major (480789)
E. Angela Murphy (480790)
Mingui Fu (79114)
Daping Fan (441395)

November 2013

<p><b>A</b>. Representative images of LDLR−/− mice received bone marrow cells from WT (WT) or MCPIP1...

Genetic Backgrounds but Not Sizes of Atherosclerotic Lesions Determine Medial Destruction in the Aortic Root of Apolipoprotein E–Deficient Mice

Weibin Shi
Morry D. Brown
Xuping Wang
Jack Wong
David F. Kallmes
Alan H. Matsumoto
Gregory A. Helm
Thomas A. Drake
Aldons J. Lusis

July 2015

Objective—Destruction of the elastic media is the most striking histologic feature of atheroscleroti...

Size and macrophage content of advanced aortic root lesions.

Robert H. Lee (715546)
Guillermo Vazquez (715547)

March 2015

<p>Atherosclerotic lesions in aortic root sections from LDLRKO mice transplanted with bone marrow fr...

Bone marrow MCPIP1 deficiency caused hematological disturbance.

Fang Yu (156838)
Fen Du (480786)
Yuzhen Wang (480787)
Shengping Huang (287849)
Ruidong Miao (480788)
Amy S. Major (480789)
E. Angela Murphy (480790)
Mingui Fu (79114)
Daping Fan (441395)

November 2013

<p><b>A</b>. Giemsa stained blood smears showed MCPIP1−/− bone marrow cell recipients contain dramat...

Analysis of atherosclerosis in the aortic root of bone marrow transplanted LDLr KO mice after 9 weeks of HF/HC diet feeding.

Bart Lammers (302835)
Ying Zhao (16546)
Menno Hoekstra (342164)
Reeni B. Hildebrand (180079)
Dan Ye (180080)
Illiana Meurs (180070)
Theo J. C. Van Berkel (2222029)
Miranda Van Eck (180084)

February 2013

<p>Quantification of atherosclerotic lesion sizes in the aortic root and TC levels in bone marrow tr...

Analysis of atherosclerosis in the aortic arch of bone marrow transplanted LDLr KO mice after 9 weeks of HF/HC diet feeding.

Bart Lammers (302835)
Ying Zhao (16546)
Menno Hoekstra (342164)
Reeni B. Hildebrand (180079)
Dan Ye (180080)
Illiana Meurs (180070)
Theo J. C. Van Berkel (2222029)
Miranda Van Eck (180084)

February 2013

<p>Relative plaque area in the aortic arch was quantified <i>en face</i> calculating the ratio of at...

Atherosclerosis in the aortic root of LDLr KO mice reconstituted with WT, ABCA1 KO, ABCA7 KO and dKO bone marrow.

Illiana Meurs (180070)
Laura Calpe-Berdiel (180072)
Kim L. L. Habets (180074)
Ying Zhao (16546)
Suzanne J. A. Korporaal (180076)
A. Mieke Mommaas (45117)
Emmanuelle Josselin (86865)
Reeni B. Hildebrand (180079)
Dan Ye (180080)
Ruud Out (180081)
Johan Kuiper (128579)
Theo J. C. Van Berkel (2222029)
Giovanna Chimini (180082)
Miranda Van Eck (180084)

March 2012

<p>(<b>A</b>) The mean lesion area (µm<sup>2</sup>) was calculated from Oil red O-stained cross-sect...

Atherosclerosis development with Western Diet Feeding.

Ricardo A. Garcia (4107238)
Mujing Yan (278971)
Debra Search (652729)
Rongan Zhang (278970)
Nancy L. Carson (278978)
Carol S. Ryan (278974)
Constance Smith-Monroy (652730)
Joanna Zheng (652731)
Jian Chen (15340)
Yan Kong (652732)
Huaping Tang (652733)
Samuel E. Hellings (278972)
Judith Wardwell-Swanson (652734)
Joseph E. Dinchuk (652735)
George C. Psaltis (278981)
David A. Gordon (278984)
Peter W. Glunz (652736)
Peter S. Gargalovic (278973)

October 2014

<p>En face plaque quantification of excised mouse aortas using oil red O. <b>A</b>) Lesion area meas...

Bone marrow–derived MCP1 required for experimental aortic aneurysm formation and smooth muscle phenotypic modulation

Moehle, Christopher W.
Bhamidipati, Castigliano M.
Alexander, Matthew R.
Mehta, Gaurav S.
Irvine, James N.
Salmon, Morgan
Upchurch, Gilbert R.
Kron, Irving L.
Owens, Gary K.
Ailawadi, Gorav

December 2011

ObjectivesThis study tested the hypothesis that monocyte chemotactic protein 1 (MCP1) is required fo...

γδT cell deficiency reduces aortic arch lesion area in Western diet-fed ApoE KO mice.

Duc M. Vu (644128)
Albert Tai (349165)
Jeffrey B. Tatro (644129)
Richard H. Karas (147803)
Brigitte T. Huber (644130)
Debbie Beasley (644131)

October 2014

<p>Mice were fed Western diet for 4 weeks and aortic root cross sections were stained with <b>A:</b>...

Development of atherosclerotic plaques in LDLR−/− PWT and LDLR−/−PKO mice fed LFD and HFD.

Tanja Steiner (542397)
Lorenza Francescut (542398)
Simon Byrne (542399)
Timothy Hughes (56285)
Archana Jayanthi (542400)
Irina Guschina (542401)
John Harwood (93890)
Katherine Cianflone (155973)
Cordula Stover (542402)
Sheila Francis (265603)

March 2014

<p><b>A</b> therosclerosis-prone mice (males and females) lacking properdin were fed low fat or high...

Aortic root atherosclerosis in Paigen diet-fed apoE KO and PDZK1/apoE dKO mice.

Ayce Yesilaltay (368962)
Kathleen Daniels (368963)
Rinku Pal (284735)
Monty Krieger (125581)
Olivier Kocher (158771)

February 2013

<p>Hearts were harvested from Paigen diet-fed apoE KO (A, C–D) and PDZK1/apoE dKO (B, E–F) mice as d...

γδT cell deficiency reduces aortic root lesion area in 24 wk-old chow-fed ApoE KO mice.

Duc M. Vu (644128)
Albert Tai (349165)
Jeffrey B. Tatro (644129)
Richard H. Karas (147803)
Brigitte T. Huber (644130)
Debbie Beasley (644131)

October 2014

<p><b>A&D:</b> Aortic root lipid-rich lesions outlined in <i>green</i> (<i>en face</i> view) are sig...