<p>(A) Representative images from the SA-β-gal assays quantified in (B). 100 nM 1,25(OH)<sub>2</sub>D<sub>3</sub> significantly induced senescence compared to the control treatment (EtOH). Bars labeled “a” or “b” are statistically significantly different from each other according to ANOVA and post-hoc Fisher’s LSD test (n = 3 replicates, ~160 cells quantified in each of 10 fields of view per replicate, critical value = 0.05). </p
“Ctr”–control cells. “Pb”–Pb-treated cells. (A) SA-β-Gal staining of Ctr and Pb-treated hMESCs. Scal...
<p>(A) Upper panel: PC12 cells were treated with DMSO or 1, 10, 50 and 100 nM TCDD for 72 h and then...
<p>PTEC were isolated and grown for 6 days in culture before being exposed to 10 Gy γ-irradiation. A...
<p>(A) HepG2 cells were cultured in RPMI medium with 0.1% DMSO or 10 µM etoposide for 0, 12, 24, 36 ...
<p>The HCT116 cells were pretreated with different concentrations of NSC666715 for 2 h followed by t...
<p>Representative immunofluorescent images from three independent experiments of MDA-MB-231, SAEC an...
<p>(A-D) Effects of D-meth (1 mM, closed bars) or vehicle (open bars) on (A) senescence-associated -...
<p>(<b>A</b>) SA-β-gal staining at 48 h after transfection of expression plasmids for E12, p21 and F...
<p>Normal (MCF12A) ± siMGMT undergo ≥ 75% senescence at equitoxic concentrations of MNNG (2 µM + siM...
<p>Subconfluent HPAEC were pretreated with 5 μM AG1024 or vehicle (DMSO) for 30 minutes, exposed to ...
<p>HCT116 cells were treated with different concentrations of TMZ for 48 h and then processed for SA...
<p>Senescence induction 24–144 h after TMZ treatment (100 µM) determined by C<sub>12</sub>FDG positi...
<p><b>A–B.</b> Pp38 MAPK mediated senescence phenotype (SP) development was determined using Senesce...
<p>After 72 hours of treatment with 5-FU (shown in μM), both cell types display a dose-dependent inc...
<p>(<b>A</b>) SA-β-gal staining increased with RV doses in both A549 cells (upper panel) and H460 ce...
“Ctr”–control cells. “Pb”–Pb-treated cells. (A) SA-β-Gal staining of Ctr and Pb-treated hMESCs. Scal...
<p>(A) Upper panel: PC12 cells were treated with DMSO or 1, 10, 50 and 100 nM TCDD for 72 h and then...
<p>PTEC were isolated and grown for 6 days in culture before being exposed to 10 Gy γ-irradiation. A...
<p>(A) HepG2 cells were cultured in RPMI medium with 0.1% DMSO or 10 µM etoposide for 0, 12, 24, 36 ...
<p>The HCT116 cells were pretreated with different concentrations of NSC666715 for 2 h followed by t...
<p>Representative immunofluorescent images from three independent experiments of MDA-MB-231, SAEC an...
<p>(A-D) Effects of D-meth (1 mM, closed bars) or vehicle (open bars) on (A) senescence-associated -...
<p>(<b>A</b>) SA-β-gal staining at 48 h after transfection of expression plasmids for E12, p21 and F...
<p>Normal (MCF12A) ± siMGMT undergo ≥ 75% senescence at equitoxic concentrations of MNNG (2 µM + siM...
<p>Subconfluent HPAEC were pretreated with 5 μM AG1024 or vehicle (DMSO) for 30 minutes, exposed to ...
<p>HCT116 cells were treated with different concentrations of TMZ for 48 h and then processed for SA...
<p>Senescence induction 24–144 h after TMZ treatment (100 µM) determined by C<sub>12</sub>FDG positi...
<p><b>A–B.</b> Pp38 MAPK mediated senescence phenotype (SP) development was determined using Senesce...
<p>After 72 hours of treatment with 5-FU (shown in μM), both cell types display a dose-dependent inc...
<p>(<b>A</b>) SA-β-gal staining increased with RV doses in both A549 cells (upper panel) and H460 ce...
“Ctr”–control cells. “Pb”–Pb-treated cells. (A) SA-β-Gal staining of Ctr and Pb-treated hMESCs. Scal...
<p>(A) Upper panel: PC12 cells were treated with DMSO or 1, 10, 50 and 100 nM TCDD for 72 h and then...
<p>PTEC were isolated and grown for 6 days in culture before being exposed to 10 Gy γ-irradiation. A...