SBGN process diagram of human liver iron metabolism model.

<p>The compartment with yellow boundary represents the hepatocyte, while the compartment with pink boundary represents plasma. Species overlayed on the compartment boundaries represent membrane-associated species. Abbreviations: Fe: iron, FPN1: ferroportin, FT: ferritin, HAMP: hepcidin, haeme: intracellular haeme, haeme_intercell: plasma haeme, HFE: human haemochromatosis protein, HO-1: haeme oxygenase 1, IRP: iron response protein, LIP: labile iron pool, Tf-Fe_intercell: plasma transferrin-bound iron, TfR1: transferrin receptor 1, TfR2: transferrin receptor 2. Complexes are represented in boxes with the component species. In the special case of the ferritin-iron complex symbol, the amounts of each species are not in stoichiometric amounts (since there are thousands of iron ions per ferritin).