Abrogation of chemokine receptor signalling does not limit CD4⁺ T cell accumulation in the livers of WSX-1^−/− mice during malaria infection.

<p>The effect of inhibitors of chemokine receptor signalling on the migration of CD4⁺ T cells from infected (D14 PI) WSX-1^−/− mice towards (A) CCL4, CCL5, (B) CXCL12 and (C) liver homogenate cells from infected (D14 pi) WSX-1^−/− mice. (D) Representative histogram and (E) numbers of CD4⁺ T cells accumulating in the livers of treated and untreated WSX-1^−/− mice (D14 pi). (F) The migration of CD4⁺ T cells from treated infected (D14 PI) WSX-1^−/− mice towards liver homogenate cells from infected (D14 PI) WSX-1^−/− mice. (G) The numbers of pertussis toxin or control treated CD4⁺ T cells accumulating in the liver on day 13 pi. Data are the mean +/− SEM of the group with 3–5 mice per group. Data are representative of 3 independent experiments. *P<0.05 between highlighted groups.