Accumulation of CD4⁺ T cells in the liver of WSX-1^−/− mice during malaria infection is caused by increased migration.

<p>(A) Representative Histograms, (B) frequencies and (C) numbers of intrahepatic CD4⁺ T cells in the liver of WT and WSX-1^−/− mice during infection. (D–G) The mean frequencies of intrahepatic CD4⁺ T cells expressing (D) BrDU, (E) Ki67 (F) annexin V⁺/7-AAD⁻ and (G) annexin V⁺/7-AAD⁺. (H–I) The migration of splenic CD4⁺ T cells from naïve, D7 and D14 infected mice towards liver homogenate cells from (H) infected (D14) or (I) naïve mice. Data are the mean +/− SEM of the group with 3–5 mice per group. Data are representative of 3 independent experiments. *P<0.05, **P<0.01 WT vs. WSX-1^−/− mice.